Headaches: Oxygen Therapy!
Declan Kennedy
| 12-01-2026

· News team
Cluster headaches are considered among the most severe headache conditions, marked by sudden attacks of intense pain that follow repeating patterns.
These episodes often appear daily for weeks or months, then disappear for long periods.
Understanding Cluster Headaches
Cluster headaches differ from common headache types in both timing and intensity. Attacks often occur at the same time each day, frequently at night, and may last from 15 minutes to several hours. Pain is usually concentrated around one eye or one side of the head and may be accompanied by restlessness or nasal congestion.
Neurological research indicates that cluster headaches involve abnormal activity in the hypothalamus, a brain region that regulates daily biological rhythms. This explains why attacks often follow precise schedules and occur in cycles. Blood vessel changes and nerve signaling disturbances also play a role, making rapid intervention especially important.
What Is Oxygen Therapy?
Oxygen therapy for cluster headaches involves breathing pure oxygen through a face mask at a high flow rate, typically delivered from a medical-grade oxygen tank. Unlike general oxygen use for breathing support, this method is designed specifically to stop headache attacks once they begin.
Treatment usually starts at the first sign of pain. Oxygen is inhaled continuously for a short period, often between 10 and 20 minutes. Many patients report noticeable relief within minutes, making this approach particularly valuable during severe attacks.
How Oxygen Therapy Reduces Pain
Although the exact mechanism is still being studied, oxygen therapy appears to work by affecting blood vessel behavior and nerve signaling in the head. High levels of oxygen may cause constricted blood vessels, counteracting the abnormal widening linked to headache pain. Oxygen also influences nerve pathways associated with pain transmission.
Dr. Peter Goadsby, a leading neurologist and headache specialist, has clearly summarized its value: “High-flow oxygen is one of the safest and most effective acute treatments for cluster headache.”
Advantages Compared to Medication
Many medications used for cluster headaches require time to take effect or may cause unwanted side effects. In contrast, oxygen therapy acts quickly and leaves the body rapidly once treatment stops. This allows patients to resume normal activity without lingering effects.
Another advantage is its compatibility with other treatments. Oxygen therapy can be used alongside preventive medications without interaction concerns. This flexibility supports individualized care plans guided by medical professionals.
Practical Considerations for Use
Oxygen therapy requires a prescription and access to appropriate equipment. A non-rebreather mask is commonly used to ensure delivery of pure oxygen without mixing with surrounding air. Flow rate and duration are determined by healthcare providers based on clinical guidelines.
Cluster headaches require fast and effective relief due to their severity and sudden onset. Oxygen therapy offers a well-supported, non-drug option that can reduce pain quickly and safely. Clinical evidence and expert guidance confirm its role as a leading acute treatment. When used correctly and under medical supervision, oxygen therapy provides meaningful relief for many individuals affected by this challenging condition.